OMass Therapeutics Announces $310 Million Series C Financing to Advance Portfolio of Small Molecule Therapeutics in Endocrinology and Immunology
OMass Therapeutics, a biotechnology company developing small molecule therapeutics against highly validated target ecosystems, led by Rosamond Deegan and the team, has announced an oversubscribed $310 million (£230 million) Series C financing round. Proceeds from the financing will support the advancement of the Company’s lead program, OMS1620, a potential best-in-class MC2 (melanocortin-2) receptor antagonist, through Phase 2 clinical development in congenital adrenal hyperplasia (CAH), as well as ACTH-dependent Cushing’s syndrome.
The round was co-led by new investors Bain Capital Life Sciences, Forbion and Novo Holdings, with additional participation from Janus Henderson Investors, SV Health Investors and Jefferson Life Sciences. Each of the Company’s existing investors also participated in the round, including Syncona, Oxford Science Enterprises, GV, Northpond Ventures, Sanofi Ventures, British Business Bank and University of Oxford.
OMS1620 is designed to increase receptor residency time and sustain activity despite rising endogenous ACTH levels, potentially enabling more patients with CAH to achieve androgen normalization with physiologic doses of glucocorticoids.
The financing will also advance OMass’ earlier-stage pipeline, including the generation of initial clinical data for a potential first-in-class SLC15A4 inhibitor targeting lupus and other diseases associated with interferon overproduction and pathogenic B-cell activation.
“This financing comes at an exciting point in OMass’ evolution as we advance OMS1620 into the clinic, with our SLC15A4 inhibitor poised to follow,” said Ros Deegan, Chief Executive Officer of OMass Therapeutics. “We have demonstrated the ability of our team and approach to discover and deliver a pipeline of first- and best-in-class programs in endocrinology and immunology into the clinic. With the backing of an outstanding group of new and existing investors, we are entering our next phase of growth with the resources to translate that progress into a portfolio of clinically differentiated medicines for patients.”
As part of the financing, Evan Greif of Bain Capital Life Sciences and Audrey Cacaly of Forbion will join the Company’s Board of Directors, while Max Klement of Novo Holdings and Ali Jazayeri of SV Health Investors will serve as Board observers.
“OMass leverages an experienced team and a clear vision for building a leading therapeutics company that translates complex biology into differentiated medicines for patients with significant unmet needs,” said Evan Greif, Principal at Bain Capital Life Sciences. “The Company is executing against that vision by advancing OMS1620 and applying its proprietary discovery approach to build a broader pipeline across endocrinology and immunology. We see meaningful potential for OMS1620 to improve the treatment for patients with CAH and look forward to partnering with Ros and the team to support the Company’s strategic and patient-first approach.”
“This financing has the potential to deliver clinical data for two differentiated programs, OMS1620 and SLC15A4, providing important opportunities to demonstrate their therapeutic potential,” said Audrey Cacaly, Principal at Forbion. “These programs are part of a pipeline built entirely through internal discovery, underscoring the productivity and breadth of OMass’ platform and its potential to generate meaningful new medicines across endocrine and immunologic diseases. We look forward to working closely with the talented OMass team as they advance these programs.”
“We are pleased to join a premier investor syndicate supporting OMass as the Company advances its breakthrough programs into the clinic,” said Max Klement, Partner, Venture Investments at Novo Holdings. “Each of these candidates has the potential to address substantial unmet patient needs in their respective areas of endocrinology and immunology, and we look forward to the Company’s continuing progress.”
